Why We Need Sufficient Oxygen
Good oxygenation leads to good heat shock proteins performance that prevents damage to tissue components and cell death after injury, including stroke and infections. It promotes tissue repair even if damage has already occurred.
Severe immune response(autoimmunity) produces acute inflammation with fever and aches, promotes apoptotic cell death from mitochondria dysfunction, and regeneration follows. Moderate immunity leads to chronic inflammation, little regeneration but rather degeneration through mesenchymal tissue replacement of functional parenchymal tissue. Little immunity leads to a carrier state with usually neither disease signs nor pain, if there is limited microbe invasiveness.
Good oxygenation leads to good tissue repair, decreased inflammation and decreased cell damage and death. Immune cells are more effective, much stronger and alert.
Oxygen, therefore, encourages repair, cell rejuvenation and, in less frequent situations of irreversible damage like in trauma, to programmed cell death and replacement. This alleviates inflammation and slows down aging, which are accompanied by massive cell injury and necrosis with some loss of cell quality and function.
These oxygen functions, from optimal ATP output, which favor cell growth, repair and replacement, lead to better gene expression, enzyme function, good immunity, metabolic balance and overall good organ function.
Oxygen free radicals result from high metabolic cellular activity, as collaterals, mirrored by aerobic respiration. High food(glucose) supply, therefore, has as a consequence, the production of superoxide anion, with the electron coming from the electron transport chain. Dying tissue, on the other hand, can cause excess unused oxygen to combine with water, to form hydrogen peroxide.
Incidentally, the oxygen superoxide, converts to the more potent hydroxyl radical by combining with hydrogen peroxide. Phagocytes synthesize hydrogen peroxide and use it, as defense, to kill microbes that invade the body. There are enzyme systems in the body which have evolved to protect the body from the harm of oxygen free radicals.
Anti-oxidants have a dual function in the body: They rid the body of toxic reactive oxygen radicals by combing irreversibly with them. They also reversibly bind with molecular oxygen, get it transported to tissues, that would otherwise have insufficient oxygen tension, due to poor blood supply, for activity. There they readily give up the molecular oxygen to the cells that need them for metabolic activity and this boosts their energy production and function. Hence, vitamin A, which is lipid soluble, will increase collagen synthesis in the skin.
In severe stress, metabolic function will be compromised as excess glucose, generated from body stores, will block the electron chain. This will promote anaerobic, as opposed to way much efficient aerobic, respiration. The meager energy resources, which would be used to support the body's defense, physical and mental functions, cell repair and renewal, are zapped away, instead, to fuel the coping or compensation mechanisms in stress. Lactic acid accumulation, from anaerobic respiration, will promote the breeding of microbes, in addition to feeding many other debilitating events.
Exercise and increased oxygen tension in tissues, by boosting metabolic function, increase mitochondria quantity and quality, which, in turn, boosts oxygen use. These activities raise endorphin levels in the brain and produce a calming effect on the mind, while boosting the immune cell and other cells' functions. Stress is reduced and this, again,helps in oxygen utilization for optimum energy resource output.
Dr Oliver Verbe Birnso,MD
Severe immune response(autoimmunity) produces acute inflammation with fever and aches, promotes apoptotic cell death from mitochondria dysfunction, and regeneration follows. Moderate immunity leads to chronic inflammation, little regeneration but rather degeneration through mesenchymal tissue replacement of functional parenchymal tissue. Little immunity leads to a carrier state with usually neither disease signs nor pain, if there is limited microbe invasiveness.
Good oxygenation leads to good tissue repair, decreased inflammation and decreased cell damage and death. Immune cells are more effective, much stronger and alert.
Oxygen, therefore, encourages repair, cell rejuvenation and, in less frequent situations of irreversible damage like in trauma, to programmed cell death and replacement. This alleviates inflammation and slows down aging, which are accompanied by massive cell injury and necrosis with some loss of cell quality and function.
These oxygen functions, from optimal ATP output, which favor cell growth, repair and replacement, lead to better gene expression, enzyme function, good immunity, metabolic balance and overall good organ function.
Oxygen free radicals result from high metabolic cellular activity, as collaterals, mirrored by aerobic respiration. High food(glucose) supply, therefore, has as a consequence, the production of superoxide anion, with the electron coming from the electron transport chain. Dying tissue, on the other hand, can cause excess unused oxygen to combine with water, to form hydrogen peroxide.
Incidentally, the oxygen superoxide, converts to the more potent hydroxyl radical by combining with hydrogen peroxide. Phagocytes synthesize hydrogen peroxide and use it, as defense, to kill microbes that invade the body. There are enzyme systems in the body which have evolved to protect the body from the harm of oxygen free radicals.
Anti-oxidants have a dual function in the body: They rid the body of toxic reactive oxygen radicals by combing irreversibly with them. They also reversibly bind with molecular oxygen, get it transported to tissues, that would otherwise have insufficient oxygen tension, due to poor blood supply, for activity. There they readily give up the molecular oxygen to the cells that need them for metabolic activity and this boosts their energy production and function. Hence, vitamin A, which is lipid soluble, will increase collagen synthesis in the skin.
In severe stress, metabolic function will be compromised as excess glucose, generated from body stores, will block the electron chain. This will promote anaerobic, as opposed to way much efficient aerobic, respiration. The meager energy resources, which would be used to support the body's defense, physical and mental functions, cell repair and renewal, are zapped away, instead, to fuel the coping or compensation mechanisms in stress. Lactic acid accumulation, from anaerobic respiration, will promote the breeding of microbes, in addition to feeding many other debilitating events.
Exercise and increased oxygen tension in tissues, by boosting metabolic function, increase mitochondria quantity and quality, which, in turn, boosts oxygen use. These activities raise endorphin levels in the brain and produce a calming effect on the mind, while boosting the immune cell and other cells' functions. Stress is reduced and this, again,helps in oxygen utilization for optimum energy resource output.
Dr Oliver Verbe Birnso,MD
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