Healthy Developmental Stress
Niacin has been described as the 'Youth Pill'. Niacin and nicotinamide are converted to NAD which boosts lipid metabolism, directly reducing oxidative stress, with the resultant conversion to NADH, which has potent anti-oxidant and anti-inflammatory properties, though oxygen free radicals are produced along the way in the metabolic path. The irritant nature of niacin which produces prostaglandins(responsible for flushing) will additionally boost metabolism through increased calcium entry into the cell, will generate free radicals and promote inflammation in a dose-dependent manner. Of interest, sirtuins(silent information regulator 2) proteins, protein deacetylators, cause the de-acetylation of acetyl-lysine residues, alongside the hydrolysis of NAD into O-acetyl-ADP-ribose, the deacetylated substrate and nicotinamide, which in an end-product inhibition manner blocks sirtuins activity. Exercise,fasting and niacin which generate NAD(the former two by oxidizing and exhausting...