Stress: A Major Factor in All Diseases
It is rapidly becoming clear that stress, both psychological and physical(physical stress or damage has a psychological component to it) is responsible for the vast majority of degenerative and age-related diseases, immune deficiencies and autoimmune diseases, metabolic diseases and cancers. And infectious diseases can be added on the list since the immune system is affected. Since genetic mutations are effected by stress, it means that genetic diseases are included as well. So basically all diseases are caused by damage to body tissue(stress).
Response to frank stress(necrosis) presents as inflammation, and cell suicide(apoptosis) occurs in less severe instances. In-between we have necroptosis and pyroptosis. For survival, our body tissues need repairs with or without autophagy(the breakdown of less needed tissues in order to have substrates to repair high priority tissues). Repair is priority to the body and the priority tissue number one, because it is so badly needed for awareness and daily survival, is the nerve tissue.
So, once stress, physical or psychological hits the nerves, the priority is for repair to take place, even if it means the breakdown of, for example, the muscle tissue(autophagy) to attain this goal. If repair is not possible, necrosis or apoptosis follows and many degenerative diseases are born out of this mishap. When repair follows nerve stress, the immune system has to be shut down, and the carrying away of pathogens and fat cells by macrophages stops, cortisol helping. Sedentary macrophages, lodged in tissues, are more damaging to organs since they are not actively clearing pathogens or fat cells and as they secrete cytokines that also govern growth, compensatory or otherwise. Fat cells and the fat therein are needed for nerve membrane stalization(repair) and must be spared. (And if ingested, at all, bacteria remain intracellular in macrophages). This predisposes to obesity and insulin tolerance. Both new monocytes, and new fat cells which normally replace old ones after being cleared by macrophages, are more effective in their respective phagocytic and storage functions
Atherosclerosis begins in blood vessels, following damage to the nerves that control blood pressure, from psychological and physical stress possibly due to chronic activation.
The culprit in most nerve damage is the amyloid, the poorly folded(misfolded) protein, which results from stress, as a consequence of the heat shock protein,(the protein folding protein), the chaperone, becoming overwhelmed. It causes damage to most nerve tissue, leads to nerve membrane destabilization and oxygen free radical production. Unlike the free oxygen radical produced by metabolism and which is rapidly converted to hydrogen peroxide, which incidentally helps fold proteins, and because the amyloid is resistant to degradation, its own free radical production overwhelms the cell, and repair fails, in spite of the priority given the nerve tissue to heal.
Nerve membrane stabilization and protein folding strategies are the key to nerve repair and, by the stretch, the prevention and management of chronic inflammation, autoimmunity and low immunity, metabolic and degenerative disease, genetic mutations and cancer. These will variably involve the use of chemical chaperones and membrane stabilizers, including, but not limited to, zinc, magnesium, potassium, niacin, small amounts of hydrogen peroxide(provided by exercise and which activates proteases to break down amyloid), glycine, taurine, phenylbutyrate, phenylacetate, medium chain fatty acids, omega-3 and unsaturates and , of course, stress avoidance( toxicants aversion) and management.
Dr. Oliver Verbe Birnso M.D.
Response to frank stress(necrosis) presents as inflammation, and cell suicide(apoptosis) occurs in less severe instances. In-between we have necroptosis and pyroptosis. For survival, our body tissues need repairs with or without autophagy(the breakdown of less needed tissues in order to have substrates to repair high priority tissues). Repair is priority to the body and the priority tissue number one, because it is so badly needed for awareness and daily survival, is the nerve tissue.
So, once stress, physical or psychological hits the nerves, the priority is for repair to take place, even if it means the breakdown of, for example, the muscle tissue(autophagy) to attain this goal. If repair is not possible, necrosis or apoptosis follows and many degenerative diseases are born out of this mishap. When repair follows nerve stress, the immune system has to be shut down, and the carrying away of pathogens and fat cells by macrophages stops, cortisol helping. Sedentary macrophages, lodged in tissues, are more damaging to organs since they are not actively clearing pathogens or fat cells and as they secrete cytokines that also govern growth, compensatory or otherwise. Fat cells and the fat therein are needed for nerve membrane stalization(repair) and must be spared. (And if ingested, at all, bacteria remain intracellular in macrophages). This predisposes to obesity and insulin tolerance. Both new monocytes, and new fat cells which normally replace old ones after being cleared by macrophages, are more effective in their respective phagocytic and storage functions
Atherosclerosis begins in blood vessels, following damage to the nerves that control blood pressure, from psychological and physical stress possibly due to chronic activation.
The culprit in most nerve damage is the amyloid, the poorly folded(misfolded) protein, which results from stress, as a consequence of the heat shock protein,(the protein folding protein), the chaperone, becoming overwhelmed. It causes damage to most nerve tissue, leads to nerve membrane destabilization and oxygen free radical production. Unlike the free oxygen radical produced by metabolism and which is rapidly converted to hydrogen peroxide, which incidentally helps fold proteins, and because the amyloid is resistant to degradation, its own free radical production overwhelms the cell, and repair fails, in spite of the priority given the nerve tissue to heal.
Nerve membrane stabilization and protein folding strategies are the key to nerve repair and, by the stretch, the prevention and management of chronic inflammation, autoimmunity and low immunity, metabolic and degenerative disease, genetic mutations and cancer. These will variably involve the use of chemical chaperones and membrane stabilizers, including, but not limited to, zinc, magnesium, potassium, niacin, small amounts of hydrogen peroxide(provided by exercise and which activates proteases to break down amyloid), glycine, taurine, phenylbutyrate, phenylacetate, medium chain fatty acids, omega-3 and unsaturates and , of course, stress avoidance( toxicants aversion) and management.
Dr. Oliver Verbe Birnso M.D.
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