Disease Mitigative Mechanisms and Strategies

Stress leads to cellular damage which necessitates frank cellular repair and growth; apoptosis, or necrosis and inflammation, that will prompt cellular proliferation and growth.

For the first mechanism to happen, there must be ant-stress strategic mechanisms in place, and operational, that prevent overt damage or are rapidly mobilized to take care of the damage before cell death ensues or inflammation and cellular proliferation take place to remedy tissue deficiency. These include repair enzymes, anti-oxidants and the rapid mobilization of food resources. A well nourished body will take this path and full tissue restoration is more likely.

On the other hand, apoptosis, or necrosis including necroptosis, will result if there is not enough protective mechanisms, the damage is excessive, repair is defective or nutritional resources are inadequate. Some tissue reorganization is more likely and recovery is unlikely to be full.

Growth hormone and proliferative factors and co-factors like steroids, vitamin D and A, zinc, calcium which act together, alone, or in tandem with inflammation, will restore tissue.

To ensure tissue full restoration--preventing cancer and reorganization-- sirt enzymes, heat shock proteins(chaperones) need to have been synthesized, mobilized and stimulated. Various signaling systems are in place to cater for this and must be fed accordingly.

If infection is the cause of stress, the causative agent needs to be removed to prevent a failed attempt to fully restore tissue. Citrate is at the center of intermediary metabolism and will provide macromolecules and ATP for synthesis. NAD not only helps in the mobilization of stored food but also summons antistress, protective mechanisms in place.

The best disease prevention strategies will involve adequate nutrition, stress prevention and management, and exercise. Most desirable disease prevention cannot take place if health is wanting, in the first place. All pre-existing diseases and conditions must be appropriately dealt with to allow this to happen.

Dr. Oliver Verbe Birnso, MD.

Comments

Post a Comment

Popular posts from this blog

The Natural Way to Lose Weight and Keep It Off

Most people express the frustration of straining to lose weight only to gain it back in a twinkle of an eye. This is because most weight loss programs are strenuous and not natural. Going to the gym is not always much fun and although you may enjoy playing tennis everyday this may not always be a practical way to lose weight, given that you may have to work on a daily basis to earn a living. If your job involves standing and talking then you may not only have the benefit of earning an income but also an opportunity to lose weight, for close to eight hours. You are more than twice able to spend calories standing than sitting. You are even luckier if your job involves body movement, since physical exercise is the best way to lose weight. If you are overweight, it is advisable to begin any exercise program slowly and build up with time. Although endurance exercise like jogging, may help you lose weight fastest, you will only keep it off if you refrain from lavishly rewarding yourself ...
Read more

How Much of Stress Do We Need?

The G1 phase of the cell cycle determines if a cell is to differentiate or not. During this phase, the cell develops protuberances(cilia) which sense the environment, effect movement and  in turn stimulate autophagy(nerve and muscle cells are much elongated from these protuberances). Levels of Nrf2, which lower levels of free radicals, fall in this pro-differentiation state. The longer the G1 the more likely the switch to differentiation from cell cycling. When there is transient fall in energy resources or growth factors, there will be less proliferation and more pro-differentiation, and when those resources later become available, more pronounced differentiation will take place. Transient spike in psychological, physical or nutritional stress will cause the engagement of the 5-phosphate pentose pathway that yields the anti-oxidant NADPH, and as well produces intermediates for protein synthesis. This promotes cellular prolif...
Read more

Fitness and Holistic Health

The body has a way of matching activity and immunity to metabolism. This is brought about through the circadian rythm. Driven by cortisol and entrained by sunlight and physical routine, this is a natural rhythm that is entrenched to all biological systems. It is governed by the major biological clock proteins  as well as organ-specific clock proteins and their negative feed-back inhibitions, which organ-specific clock proteins are different for different organs, and hence we have different times at which different organs' metabolic activities and functions peak. The clock proteins affect metabolism at the level of transcription in the nucleus. The body has to manage the limited energy resources carefully so that each organ's and system's needs are adequately catered to. To do this, different tissues have optimal functional activities at different times. However, the circadian rhythm is usually reprogramed when life-threatening and stressful contingencies avail, such as c...
Read more