The Role of Spirochetes in Alzheimer's and Neurodegeneration
Alzheimer's disease has been associated with spirochetes. Quotient sensing, salt, water, temperature and antibiotic use are known triggers of biofilm formation and are variably responsible for eczema(staphylococcus), psoriasis(streptococcus) and arthritis(streptococcus). The biofilm matrix consists of exopolysaccharides held together with microbial amyloid-like proteins, stabilized by DNA; the less viscous dextrin/more viscous dextran glue that eventually polymerize to a rock-solid plaque upon exclusion of water. Dextrin is formed upon the action of hexosaminidase(lysozyme) on peptidoglycan and is a feature of the mast cell as well as the spirochete, while dextran is made from sucrose by bacteria. Spirochetes easily pass through the blood-brain barrier. The Toll-like receptor 2 activation, in response to the amyloid-like protein, curli, from the spirochete in biofilm, generates NF-kB(nuclear factor kappa beta) and TNF-alpha(tumor necrotic factor alpha) which are the first respon...