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Showing posts from September, 2017

The Role of Spirochetes in Alzheimer's and Neurodegeneration

Alzheimer's disease has been associated with spirochetes. Quotient sensing, salt, water, temperature and antibiotic use are known triggers of biofilm formation and are variably responsible for eczema(staphylococcus), psoriasis(streptococcus) and arthritis(streptococcus). The biofilm matrix consists of exopolysaccharides held together with microbial amyloid-like proteins, stabilized by DNA; the less viscous dextrin/more viscous dextran glue that eventually polymerize to a rock-solid plaque upon exclusion of water. Dextrin is formed upon the action of hexosaminidase(lysozyme) on peptidoglycan and is a feature of the mast cell as well as the spirochete, while dextran is made from sucrose by bacteria. Spirochetes easily pass through the blood-brain barrier.  The Toll-like receptor 2 activation, in response to the amyloid-like protein, curli, from the spirochete in biofilm, generates NF-kB(nuclear factor kappa beta) and TNF-alpha(tumor necrotic factor alpha) which are the first respon...

Fitness and Holistic Health

The body has a way of matching activity and immunity to metabolism. This is brought about through the circadian rythm. Driven by cortisol and entrained by sunlight and physical routine, this is a natural rhythm that is entrenched to all biological systems. It is governed by the major biological clock proteins  as well as organ-specific clock proteins and their negative feed-back inhibitions, which organ-specific clock proteins are different for different organs, and hence we have different times at which different organs' metabolic activities and functions peak. The clock proteins affect metabolism at the level of transcription in the nucleus. The body has to manage the limited energy resources carefully so that each organ's and system's needs are adequately catered to. To do this, different tissues have optimal functional activities at different times. However, the circadian rhythm is usually reprogramed when life-threatening and stressful contingencies avail, such as c...