BiTherapca Health

An irrefutable body of research continues to cumulate, showing that physical exercise is good for health. Its obvious and desirable effects are on lean body weight and muscle tone which are good for esthetics, wellness and fitness. Especially astounding are the health benefits it gives. Exercise promotes autophagy, which in normal 'doses', is followed by rejuvenation of tissue through growth factors and, from prompting protective antioxidant mechanisms, sensed by increased NAD/DADH ratio, which governs the epigenetics of histone deacetylation. A higher or prolonged 'dose' of exercise will lead to more drastic autophagy and increased pRb-dependent mitochondrial metabolism that produces oxygen free radicals which in turn favor cell death--and so it is anticancer, and pRb is an anti-oncogene, being a tumor suppressor, in this capacity. It, however, turns out that pRb may become oncogenic when in the presence of a proto-oncogene such as growth factors, since apoptosi...

It is becoming more and more clear that the living cell via its genome is aware of and senses its environment and adjusts(adapts) to it. The environment, on its own part, affects the genes directly through mutations or indirectly, by modifying their expression, epigenetically in a physical or steric alteration of the heterochromatin and euchromatin, and with the introduction of chemical tags on genes through, for example, DNA methylation and acetylation. The genome senses itself through its sensing genes and their proteins, and makes the necessary adjustments to sustain life, by correcting damage done or adopting new 'lifestyle' if damage is permanent but not lethal. Genes exposed to the outer environment are not expressed because of the influence of inhibitory factors from without, while the inner ones, shielded from such influences, are expressed. These sensors equally determine species body architecture. The master gene which determines the body plan binds many transcr...