Health, Wellness and Fitness
Alzheimer's, Parkinson's and diabetes have all been associated with stress, inflammation and overwhelmed autophagy. Here, biological clocks are marked by altered epigenetics, shortening of telomeres and mitochondrial fission. Senescence is a characteristic of biological aging and decreased repair and growth. Infections, amyloid and stress affect senescence. Stress comes in various forms; nutritional/metabolic, infectious, environmental, psychological and manifested by unfolding of proteins(ER stress), oxidation of tissue by reactive oxygen species, and damage. Although the stress response sets in, it may be overwhelmed in due course and the damage becomes evident, leading to apoptosis, senescence, inflammation and inflammatory cell death. This may further lead to autoimmunity and reactive tissue growth. While senescent cells will survive and cause inflammation, they prevent out-of-control growth, characteristic of cancers, as this draws in immune cells to take care of cance...