Gene Regulation with Diet
Nuts, whole grains, beans, fruits, vegetables are all rich in biogenic 1,3/1,4 polyamines, namely spermidine, spermine and putrescine, which, known to stabilize the DNA, improve the circadian rhythm, regulate metabolism, prevent aging and prolong healthspan. They do so, by decreasing enhanced DNA methylation, a marker seen in aging and known to be transmitted through generations of progenies. Polyamines do so, by taking up and owning the methyl group and sparing the methyl group attachment to the DNA base pairs. In fact, cancer and senescent cells grow and survive partly due to high levels of polyamines they possess. Adult mast cells store cationic polyamines in their granules, attched to sulfated heparan, and proliferate partly due to them, as well as a result of expressing the stem cell factor(SCF) receptor, c-KIT. SCF ligand is mostly supplied by fibroblasts and endothelial cells in the niche. All human cells posses these polyamines, biosynthesized from amino acid...